Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20321771 | 0.81 | NPC1 (0.54) | NPC1RAB9ATSHRHTR7HTT | |
| SCHEMBL14125145 | 0.80 | GAA (0.56) | NPC1RAB9ATSHRHTTMGAM | |
| SCHEMBL1528898 | 0.77 | TDP1 (0.44) | NPC1TSHRMGAMGAASI | |
| SCHEMBL4908475 | 0.77 | TDP1 (0.44) | NPC1TSHRMGAMGAASI | |
| SCHEMBL5155559 | 0.77 | NPC1 (0.48) | NPC1RAB9ATSHRHTR7HTT | |
| SCHEMBL6267736 | 0.77 | NPC1 (0.48) | NPC1RAB9ATSHRHTR7HTT | |
| SCHEMBL27537379 | 0.75 | AKR1C3 (0.52) | NPC1RAB9ATSHRHTR7HTT | |
| SCHEMBL5157744 | 0.74 | ENPP2 (0.50) | NPC1RAB9ATSHRHTR7HTT | |
| SCHEMBL5827764 | 0.74 | NPC1 (0.63) | NPC1RAB9ATSHRHTTMGAM | |
| SCHEMBL1355299 | 0.73 | NPC1 (0.50) | NPC1RAB9ATSHRHTR7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742916-A1 | PHENYL COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108369-A1 | PHENYL COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2005-11-17 | — | — | WO | disclosed |