SCHEMBL1355299

SCHEMBL1355299

COc1ccccc1-c1ccc(Br)cc1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.50
HTT P42858 1/20 0.50
PDE3B Q13370 1/20 0.45
PDE3A Q14432 1/20 0.45
ALOX5AP P20292 1/20 0.44
FEN1 P39748 1/20 0.44
ACHE P22303 2/20 0.43
ACLY P53396 1/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TP53 P04637 1/20 0.42
HSD17B10 Q99714 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
APP P05067 1/20 0.42
AMY1A P0DUB6 1/20 0.42
PTPRC P08575 1/20 0.41
PTPN1 P18031 1/20 0.41
TSHR P16473 1/20 0.41
BCHE P06276 1/20 0.41
MAPK14 Q16539 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27164750 0.87 BRD4 (0.43) NPC1HTTACHEACLYSMN1; SMN2
SCHEMBL24502998 0.86 AMY1A (0.45) NPC1HTTACHEACLYAMY1A
SCHEMBL28399793 0.86 MAPK1 (0.41) NPC1HTTALOX5APFEN1RAB9A
SCHEMBL11865786 0.84 MAPK14 (0.52) NPC1HTTPDE3BPDE3AALOX5AP
SCHEMBL20321771 0.83 NPC1 (0.54) NPC1HTTRAB9ASMN1; SMN2TP53
SCHEMBL29991342 0.83 ACHE (0.46) NPC1HTTACHEACLYAMY1A
SCHEMBL20110016 0.83 ACHE (0.46) NPC1HTTACHEACLYAMY1A
SCHEMBL9105602 0.82 NPC1 (0.44) NPC1HTTACHEACLYRAB9A
SCHEMBL21756115 0.81 ACHE (0.46) NPC1HTTACHEACLYRAB9A
SCHEMBL1638395 0.81 APP (0.50) PDE3BPDE3AALOX5APFEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4474446-B1 ELECTROCHROMIC COMPOUNDS, COMPOSITIONS AND DEVICES COMPRISING THE SAME ESSILOR INT (FR) 2025-12-17 EP disclosed
US-20250333380-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME IDEMITSU KOSAN CO.,LTD. (JP) 2025-10-30 US disclosed
US-12232414-B2 Aromatic amine derivatives and organic electroluminescent elements using same IDEMITSU KOSAN CO., LTD. (JP) 2025-02-18 US disclosed
WO-2024251948-A1 ELECTROCHROMIC COMPOUNDS, COMPOSITIONS AND DEVICES COMPRISING THE SAME ESSILOR INTERNATIONAL (FR) 2024-12-12 WO disclosed
EP-4474446-A1 ELECTROCHROMIC COMPOUNDS, COMPOSITIONS AND DEVICES COMPRISING THE SAME Essilor International (FR) 2024-12-11 EP disclosed
CN-110785863-B Organic photodiode and display device 三星SDI株式会社 2023-09-12 CN disclosed
US-20220255005-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME IDEMITSU KOSAN CO.,LTD. (JP) 2022-08-11 US disclosed
US-11345686-B2 Aromatic amine derivative, and organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2022-05-31 US disclosed
US-11335858-B2 Aromatic amine derivatives and organic electroluminescent elements using same IDEMITSU KOSAN CO., LTD. (JP) 2022-05-17 US disclosed
CN-110785863-A Organic photodiode and display device 三星SDI株式会社 2020-02-11 CN disclosed
EP-2484665-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT Idemitsu Kosan Co., Ltd. (JP) 2012-08-08 EP disclosed
US-20120181524-A1 NITROGEN-CONTAINING AROMATIC HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-07-19 US disclosed
US-20120175600-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2012-07-12 US disclosed
US-20120161119-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2012-06-28 US disclosed
EP-2468725-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME Idemitsu Kosan Co., Ltd. (JP) 2012-06-27 EP disclosed
US-20120146014-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-06-14 US disclosed
US-20110278551-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO., LTD. (JP) 2011-11-17 US disclosed
EP-2364980-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT Idemitsu Kosan Co., Ltd. (JP) 2011-09-14 EP disclosed
EP-2295421-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME Idemitsu Kosan Co., Ltd. (JP) 2011-03-16 EP disclosed
US-20100001636-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120175600-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT TYR, SLC7A5, SLC18A1 NPC1 2643/4885HTT 1878/4885PDE3B 2468/4885
US-20220255005-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME AOC2, AHR, AOC3 NPC1 3761/4885HTT 1597/4885PDE3B 4152/4885
US-20120181524-A1 NITROGEN-CONTAINING AROMATIC HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME AOC3, NPR3, NR0B1 NPC1 4494/4885HTT 3236/4885PDE3B 3148/4885
US-20120161119-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE TYR, TERF2, SAT1 NPC1 2581/4885HTT 1430/4885PDE3B 3116/4885
US-20120146014-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME PNMT, TYR, AOC2 NPC1 3475/4885HTT 1033/4885PDE3B 3061/4885
US-20250333380-A1 AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME ARSA, AHR, AOC2 NPC1 4432/4885HTT 948/4885PDE3B 3928/4885
US-20110278551-A1 AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT SLC7A5, ALKBH3, TYR NPC1 2725/4885HTT 2258/4885PDE3B 2228/4885
US-11345686-B2 Aromatic amine derivative, and organic electroluminescent element TYR, LEF1, EFNA1 NPC1 2818/4885HTT 4081/4885PDE3B 808/4885
US-12232414-B2 Aromatic amine derivatives and organic electroluminescent elements using same AOC2, AHR, AOC3 NPC1 3761/4885HTT 1597/4885PDE3B 4152/4885
US-11335858-B2 Aromatic amine derivatives and organic electroluminescent elements using same RER1, NR4A1, REL NPC1 4520/4885HTT 2615/4885PDE3B 3649/4885
US-20100001636-A1 AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE TYR, TERF2, SAT1 NPC1 2635/4885HTT 1677/4885PDE3B 3040/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.