Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206651 | 0.89 | EPHX2 (0.46) | HPGDEPHX2LTA4HALDH1A1KMT2A | |
| SCHEMBL206111 | 0.84 | SSTR4 (0.41) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL206288 | 0.84 | ALDH1A1 (0.50) | HPGDEPHX2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL208454 | 0.83 | ALDH1A1 (0.53) | HPGDEPHX2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL206578 | 0.82 | ALDH1A1 (0.45) | HPGDALDH1A1KMT2ASMN1; SMN2RXFP1 | |
| SCHEMBL207315 | 0.82 | ALDH1A1 (0.44) | HPGDEPHX2ALDH1A1KMT2AMAPT | |
| SCHEMBL206736 | 0.82 | HPGD (0.48) | HPGDEPHX2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL5159686 | 0.82 | NPC1 (0.40) | ALDH1A1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL4084112 | 0.81 | HPGD (0.45) | HPGDALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL207581 | 0.81 | POLB (0.46) | HPGDEPHX2KMT2ARXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007536323-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1745010-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-01-24 | — | — | EP | claimed |
| WO-2005110974-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |