Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28335756 | 0.82 | SMN1; SMN2 (0.61) | MEN1KMT2AALDH1A1TAAR1SMN1; SMN2 | |
| SCHEMBL2192778 | 0.81 | NTRK1 (0.44) | CNR1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL30606833 | 0.81 | ATR (0.64) | CNR1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7634 | 0.79 | EPHX2 (0.70) | KMT2AALDH1A1TAAR1SMN1; SMN2TP53 | |
| Benzene SCHEMBL28162617 | 0.79 | EPHX2 (0.70) | KMT2AALDH1A1TAAR1SMN1; SMN2TP53 | |
| Malonic Acid SCHEMBL11758985 | 0.79 | SLC22A12 (0.47) | CNR1LMNATSHRPOLBHTT | |
| Iodide SCHEMBL5706290 | 0.77 | EPHX2 (0.67) | KMT2AALDH1A1TAAR1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL9156069 | 0.77 | EPHX2 (0.67) | KMT2AALDH1A1TAAR1SMN1; SMN2TP53 | |
| Fluoride SCHEMBL10885265 | 0.77 | EPHX2 (0.67) | KMT2AALDH1A1TAAR1SMN1; SMN2TP53 | |
| Water SCHEMBL9215020 | 0.77 | EPHX2 (0.67) | KMT2AALDH1A1TAAR1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458690-B1 | 5,6-DIARYL-PYRAZINE-2-AMIDE DERIVATIVES AS CB1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | claimed |