Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.50 |
| ▸ | KDM5A | P29375 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5158735 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HCAR2KDM5ACA12CA1 | |
| Maleic Acid SCHEMBL5874774 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HCAR2KDM5ACA12CA1 | |
| Fumaric Acid SCHEMBL5874514 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HCAR2KDM5ACA12CA1 | |
| Maleic Acid SCHEMBL5874769 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HCAR2KDM5ACA12CA1 | |
| Fumaric Acid SCHEMBL5158743 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HCAR2KDM5ACA12CA1 | |
| Fumaric Acid SCHEMBL1131856 | 0.92 | ALDH1A1 (0.50) | ALDH1A1HCAR2KDM5ACA12CA1 | |
| Fumaric Acid SCHEMBL5874569 | 0.85 | TSHR (0.47) | ALDH1A1HCAR2CA12CA9ZDHHC20 | |
| Fumaric Acid SCHEMBL5874553 | 0.85 | TSHR (0.47) | ALDH1A1HCAR2CA12CA9ZDHHC20 | |
| Fumaric Acid SCHEMBL5874558 | 0.85 | TSHR (0.47) | ALDH1A1HCAR2CA12CA9ZDHHC20 | |
| Maleic Acid SCHEMBL5874574 | 0.85 | TSHR (0.47) | ALDH1A1HCAR2CA12CA9ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159334-B1 | PROCESS FOR THE MANUFACTURE OF FUNCTIONALIZED POLYPHENYLENE ETHERS | GEN ELECTRIC (US) | 2007-01-17 | — | — | EP | claimed |
| US-6417274-B1 | OXIDATIVE COUPLING IN SOLUTION OF MONOVLENT PHENOL USING OXYGEN CONTAINING GAS; CATALYSIS WITH METAL COMPLEX; FUNCTIONALIZING POLYPHENYLENE ETHER DURING ISOLATION STEP FOR DEVOLATILIZATION | GENERAL ELECTRIC CO. | 2002-07-09 | — | — | US | claimed |
| EP-0250979-B1 | Trialkyalmine salt-functionalized polyphenylene ethers, methods for their preparation, and compositions containing them | GEN ELECTRIC (US) | 1993-10-20 | — | — | EP | claimed |
| US-4889889-A | BLENDS WITH POLYAMIDE, POLYESTERS | GENERAL ELECTRIC COMPANY (US) | 1989-12-26 | — | — | US | claimed |
| EP-0250979-A2 | Trialkyalmine salt-functionalized polyphenylene ethers, methods for their preparation, and compositions containing them | GENERAL ELECTRIC COMPANY (US) | 1988-01-07 | — | — | EP | claimed |
| EP-1240262-B1 | POWDER COATING COMPOSITIONS | GEN ELECTRIC (US) | 2007-01-31 | — | — | EP | disclosed |
| EP-1159334-B1 | PROCESS FOR THE MANUFACTURE OF FUNCTIONALIZED POLYPHENYLENE ETHERS | GEN ELECTRIC (US) | 2007-01-17 | — | — | EP | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| EP-1061102-B1 | Polyphenylene ether/polyamide compositions | GEN ELECTRIC (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6784260-B2 | THERMOSETTING RESIN AND AT LEAST ONE POLY(PHENYLENE ETHER); HAVE EXCELLENT FRACTURE TOUGHNESS AND THERMAL PROPERTIES | GENERAL ELECTRIC COMPANY | 2004-08-31 | — | — | US | disclosed |
| US-20030236361-A1 | Powder coating compositions | CITIBANK, N.A., AS COLLATERAL AGENT | 2003-12-25 | — | — | US | disclosed |
| EP-0962495-B1 | A curable polyphenylene ether-thermosetting resin composition | GEN ELECTRIC (US) | 2003-07-09 | — | — | EP | disclosed |
| EP-0747438-A2 | Compatible compositions of poly(phenylene ether) resins and polyester resins | GENERAL ELECTRIC COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747436-A2 | Compositions of poly(phenylene ether) and polyamide resins | GENERAL ELECTRIC COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0732369-A2 | Compositions of poly(phenylene ether), poly(arylene sulfide) polyester resins, and a compatibilizer compound | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0732370-A2 | Poly(phenylene ether) compositions | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0732368-A2 | Flame retarded compositions of poly(phenylene ether), poly (arylene sulfide) and siloxane copolymer resins | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0732371-A2 | Composition of poly(phenylene ether), poly(arylene sulfide) and maleimide compounds | GENERAL ELECTRIC COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| EP-0550210-A1 | Polyphenylene ether/polyamide compositions | GENERAL ELECTRIC COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550206-A2 | Polyphenylene ether/polyamide compositions | GENERAL ELECTRIC COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |