SCHEMBL5158052

SCHEMBL5158052

COC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.79
HPGD P15428 3/20 0.79
ALDH1A1 P00352 2/20 0.79
L3MBTL1 Q9Y468 2/20 0.79
HTT P42858 2/20 0.79
TP53 P04637 1/20 0.79
SMN1; SMN2 Q16637 1/20 0.79
ELANE P08246 1/20 0.67
PRTN3 P24158 1/20 0.67
TSHR P16473 3/20 0.66
KDM4E B2RXH2 2/20 0.66
USP2 O75604 1/20 0.66
HSD17B10 Q99714 1/20 0.66
KEAP1 Q14145 2/20 0.65
GAA P10253 3/20 0.63
KMT2A Q03164 3/20 0.63
MEN1 O00255 1/20 0.63
NPC1 O15118 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
MAPK1 P28482 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2477690 0.89 LMNA (0.70) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL30486834 0.89 LMNA (0.70) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL13011714 0.88 KMT2A (0.74) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL4801356 0.87 LMNA (0.69) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL1495939 0.87 FFAR4 (0.80) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL13999329 0.86 LMNA (0.63) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL3278881 0.86 LMNA (0.63) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL13999327 0.86 ELANE (0.63) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL23200347 0.85 KEAP1 (0.65) LMNAHPGDALDH1A1L3MBTL1HTT
SCHEMBL12768028 0.85 KEAP1 (0.81) LMNAHPGDALDH1A1L3MBTL1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1777214-A2 Novel aryloxy-alkyl-dialkylamines Wyeth (US) 2007-04-25 EP disclosed
EP-1025077-B1 NOVEL ARYLOXY-ALKYL-DIALKYLAMINES WYETH CORP (US) 2007-02-28 EP disclosed
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
US-6268504-B1 USED IN THE PRODUCTION OF PHARMACEUTICAL PRODUCTS AMERICAN HOME PRODUCTS CORPORATION 2001-07-31 US disclosed
US-6242605-B1 Aryloxy-alkyl-dialkylamines AMERICAN HOME PRODUCTS CORPORATION 2001-06-05 US disclosed
EP-1025077-A1 NOVEL ARYLOXY-ALKYL-DIALKYLAMINES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-08-09 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1999019293-A1 NOVEL ARYLOXY-ALKYL-DIALKYLAMINES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-04-22 WO disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed