SCHEMBL5158060

SCHEMBL5158060

N=C(N)NC(=N)NC1=CC(Cl)CC=C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21991049 0.71
SCHEMBL14985470 0.70
SCHEMBL12830355 0.65
SCHEMBL891475 0.61 IDO1 (0.46)
SCHEMBL3068902 0.60 F2 (0.43)
Hydrochloric Acid SCHEMBL16702230 0.60 IDO1 (0.44)
4-Chlorophenylbiguanide SCHEMBL7207570 0.58 NPC1 (0.48)
SCHEMBL8265754 0.58
4-Chlorophenylbiguanide SCHEMBL305068 0.57 NPC1 (0.53)
SCHEMBL3068904 0.57 GAA (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218491-B1 DNA ENCODING A HUMAN SUBUNIT 5-HT3-C OF THE 5-HT3 SEROTONIN RECEPTOR ORTHO MCNEIL PHARM INC (US) 2007-02-07 EP disclosed
US-7109296-B2 Human 5-HT3-C protein ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2006-09-19 US disclosed
US-20050124795-A1 DNA encoding a human subunit 5-HT3-C of the 5-HT3 serotonin receptor DUBIN ADRIENNE E (US) 2005-06-09 US disclosed
EP-1185549-A4 DNA ENCODING A HUMAN SUBUNIT OF THE 5-HT3 SEROTONIN RECEPTOR ORTHO MCNEIL PHARM INC (US) 2004-04-28 EP disclosed
EP-1218491-A4 DNA ENCODING A HUMAN SUBUNIT 5-HT3-C OF THE 5-HT3 SEROTONIN RECEPTOR ORTHO MCNEIL PHARM INC (US) 2003-05-28 EP disclosed
US-20020137138-A1 DNA encoding a human subunit 5-HT3-C of the 5-HT3 serotonin receptor DUBIN ADRIENNE E (US) 2002-09-26 US disclosed
EP-1218491-A1 DNA ENCODING A HUMAN SUBUNIT 5-HT3-C OF THE 5-HT3 SEROTONIN RECEPTOR Ortho-McNeil Pharmaceutical, Inc. (US) 2002-07-03 EP disclosed
US-6365370-B1 DNA WHICH CODES FOR 5-HYDROXYTRYPTAMINE 3-C PROTEIN OF DEFINED AMINO ACID SEQUENCE; ANTIINFLAMMATORY AGENTS; TREATMENT OF HUNTINGTON'S DISEASE, ALZHEIMER'S DISEASE AND OTHERS ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-04-02 US disclosed
EP-1185549-A2 DNA ENCODING A HUMAN SUBUNIT OF THE 5-HT3 SEROTONIN RECEPTOR Ortho-McNeil Pharmaceutical, Inc. (US) 2002-03-13 EP disclosed
WO-2000071741-A9 DNA ENCODING A HUMAN SUBUNIT OF THE 5-HT3 SEROTONIN RECEPTOR ORTHO MCNEIL PHARM INC (US) 2001-07-26 WO disclosed
WO-2001016297-A1 DNA ENCODING A HUMAN SUBUNIT 5-HT3-C OF THE 5-HT3 SEROTONIN RECEPTOR ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2001-03-08 WO disclosed
WO-2000071741-A2 DNA ENCODING A HUMAN SUBUNIT OF THE 5-HT3 SEROTONIN RECEPTOR ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-11-30 WO disclosed