Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159940 | 0.91 | OPRM1 (0.40) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6941375 | 0.89 | OPRM1 (0.41) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6938750 | 0.89 | OPRM1 (0.40) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL5158611 | 0.88 | OPRM1 (0.41) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6939344 | 0.88 | OPRL1 (0.45) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6937026 | 0.88 | OPRM1 (0.40) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6936278 | 0.87 | SLC6A3 (0.44) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6939119 | 0.87 | SLC6A4 (0.45) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6934471 | 0.86 | OPRM1 (0.44) | OPRM1OPRL1SLC6A9SLC6A5SLC6A4 | |
| SCHEMBL6941657 | 0.86 | OPRM1 (0.36) | OPRM1CNR2OPRD1OPRK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1406857-B1 | SUBSTITUTED 1-ARYL-BUT-3-ENYLAMINE AND 1-ARYL-BUT-2-ENYLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2007-02-21 | — | — | EP | disclosed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |