Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.46 |
| ▸ | BACE1 | P56817 | 11/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860110 | 0.89 | BACE1 (0.45) | HCAR3BACE1PTGS2TLR8 | |
| SCHEMBL5159403 | 0.88 | BACE1 (0.42) | HCAR3BACE1KDM4EALDH1A1LMNA | |
| SCHEMBL4526201 | 0.80 | BACE1 (0.45) | BACE1MAPTKDM4DKDM4EALDH1A1 | |
| SCHEMBL5158285 | 0.80 | HCAR3 (0.50) | HCAR3GAAMAPTKDM4DKDM4E | |
| SCHEMBL3857905 | 0.79 | HCAR3 (0.45) | HCAR3BACE1 | |
| SCHEMBL3853328 | 0.79 | HCAR3 (0.45) | HCAR3BACE1 | |
| SCHEMBL3860002 | 0.78 | HCAR3 (0.44) | HCAR3BACE1 | |
| SCHEMBL3855704 | 0.78 | HCAR3 (0.44) | HCAR3BACE1 | |
| SCHEMBL7945785 | 0.78 | BACE1 (0.64) | BACE1KDM4D | |
| SCHEMBL4531419 | 0.78 | BACE1 (0.64) | BACE1KDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |