Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159393 | 0.87 | TLR8 (0.42) | HCAR3GAAMAPTTLR8ALDH1A1 | |
| SCHEMBL5158850 | 0.80 | HCAR3 (0.55) | HCAR3GAAMAPTTLR8KDM4D | |
| SCHEMBL3857907 | 0.80 | HCAR3 (0.47) | HCAR3KDM4DPTGS2 | |
| SCHEMBL3853331 | 0.80 | HCAR3 (0.47) | HCAR3KDM4DPTGS2 | |
| SCHEMBL5158280 | 0.80 | HCAR3 (0.46) | HCAR3GAAMAPTTLR8KDM4D | |
| SCHEMBL2259073 | 0.79 | PTGS2 (0.41) | KDM4DALDH1A1TSHRHIF1APTGS2 | |
| SCHEMBL11676816 | 0.79 | HCAR3 (0.54) | HCAR3GAAMAPTTLR8KDM4D | |
| SCHEMBL3854003 | 0.77 | HCAR3 (0.43) | HCAR3KDM4DPTGS2CLK2GSK3B | |
| SCHEMBL3855072 | 0.77 | HCAR3 (0.44) | HCAR3KDM4DCA2SMN1; SMN2 | |
| SCHEMBL6646676 | 0.75 | HCAR3 (0.55) | HCAR3GAAMAPTKDM4DCISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |