Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 6/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156038 | 0.96 | HTR6 (0.48) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5158824 | 0.94 | HTR6 (0.51) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5158358 | 0.88 | HTR6 (0.46) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5162250 | 0.87 | REN (0.44) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5161560 | 0.87 | SLC6A2 (0.47) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5156467 | 0.86 | SLC6A2 (0.47) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5158767 | 0.86 | SLC6A2 (0.46) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5161532 | 0.86 | HTR6 (0.43) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5158432 | 0.85 | HTR6 (0.42) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5156808 | 0.84 | HTR6 (0.46) | HTR6SLC6A4SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748984-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005110987-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |