Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.56 |
| ▸ | KDM6B | O15054 | 2/20 | 0.56 |
| ▸ | ASPH | Q12797 | 8/20 | 0.51 |
| ▸ | KDM8 | Q8N371 | 8/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11483905 | 0.75 | KDM6B (0.45) | KDM4CKDM6BMAPK8KDM4EHCAR3 | |
| SCHEMBL28859305 | 0.73 | POLB (0.50) | KDM4CKDM6BMAPK8KDM4EHCAR3 | |
| SCHEMBL11035377 | 0.73 | TLR8 (0.45) | HCAR3TLR8 | |
| SCHEMBL17378640 | 0.72 | KDM4C (1.00) | KDM4CKDM6BKDM4E | |
| SCHEMBL28310186 | 0.72 | CNR2 (0.50) | KDM4CKDM6BMAPK8HCAR3CA12 | |
| SCHEMBL15635912 | 0.72 | KDM4E (0.62) | KDM4CKDM6BMAPK8KDM4EHCAR3 | |
| SCHEMBL11087674 | 0.71 | MAPK8 (0.51) | KDM4CKDM6BMAPK8HCAR3 | |
| SCHEMBL11344172 | 0.69 | KDM4D (0.76) | KDM4CKDM6BASPHKDM8MAPK8 | |
| SCHEMBL28278344 | 0.69 | CA12 (0.49) | KDM4CKDM6BASPHKDM8KDM4E | |
| SCHEMBL28001041 | 0.69 | ASPH (0.51) | KDM4CKDM6BASPHKDM8MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |