Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.59 |
| ▸ | KDM6B | O15054 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ASPH | Q12797 | 4/20 | 0.50 |
| ▸ | RIOX2 | Q8IUF8 | 4/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 4/20 | 0.50 |
| ▸ | CISD1 | Q9NZ45 | 7/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884483 | 0.76 | CISD1 (0.63) | KDM4CKDM6BKDM4ECISD1HCAR3 | |
| SCHEMBL17378640 | 0.75 | KDM4C (1.00) | KDM4CKDM6BKDM4E | |
| SCHEMBL17363127 | 0.74 | CISD1 (0.56) | KDM4CKDM6BKDM4ECISD1HCAR3 | |
| SCHEMBL15636197 | 0.72 | KDM6B (0.54) | KDM4CKDM6BKDM4ECISD1HCAR3 | |
| SCHEMBL11087674 | 0.71 | MAPK8 (0.51) | KDM4CKDM6BHCAR3MAPK8 | |
| SCHEMBL18993722 | 0.71 | CISD1 (0.66) | KDM4CKDM6BKDM4ECISD1HCAR3 | |
| Hydrochloric Acid SCHEMBL3855171 | 0.70 | KDM6B (0.43) | KDM4CKDM6BKDM4ECISD1HCAR3 | |
| SCHEMBL993102 | 0.70 | HPGD (0.65) | KDM4CKDM6BKDM4EMAPK8 | |
| SCHEMBL9824061 | 0.70 | PLK1 (0.64) | KDM4CKDM6BCISD1HCAR3 | |
| SCHEMBL22097708 | 0.70 | HCAR3 (0.60) | KDM4CKDM6BKDM4ECISD1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |