SCHEMBL51589

SCHEMBL51589

COC(=O)c1ccc(Cl)c(N)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.66
ALDH1A1 P00352 8/20 0.66
HPGD P15428 6/20 0.66
MAPT P10636 3/20 0.66
GAA P10253 3/20 0.66
HSD17B10 Q99714 3/20 0.66
GLA P06280 1/20 0.66
CASP1 P29466 1/20 0.66
CASP7 P55210 1/20 0.66
ATM Q13315 1/20 0.66
LMNA P02545 3/20 0.57
NPSR1 Q6W5P4 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
USP2 O75604 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.53
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
MAPK1 P28482 2/20 0.52
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30391548 1.00 KDM4E (0.66) KDM4EALDH1A1HPGDMAPTGAA
Hydrochloric Acid SCHEMBL4717368 0.98 KDM4E (0.64) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL11146587 0.89 ALDH1A1 (0.54) KDM4EALDH1A1HPGDMAPTGAA
Ethyl Acetate SCHEMBL938111 0.87 HPGD (0.52) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL11307886 0.87 ALDH1A1 (0.65) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL11142510 0.85 PRSS1 (0.58) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL826694 0.85 ALDH1A1 (0.61) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL12373225 0.83 KDM4E (0.52) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL5393044 0.82 ALDH1A1 (0.64) KDM4EALDH1A1HPGDMAPTGAA
SCHEMBL192100 0.82 KDM4E (0.72) KDM4EALDH1A1HPGDMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 359 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8653305-B2 Compound having S1P receptor binding potency and use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2014-02-18 US claimed
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
EP-4720044-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD Beactica Therapeutics AB (SE) 2026-04-08 EP disclosed
US-12509424-B2 Compound and composition as PDGF receptor kinase inhibitor NIPPON SHINYAKU CO., LTD. (JP) 2025-12-30 US disclosed
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
EP-4516777-A2 COMPOUND AND COMPOSITION AS PDGF RECEPTOR KINASE INHIBITOR Nippon Shinyaku Co., Ltd. (JP) 2025-03-05 EP disclosed
CN-119431366-A IRAK4 degradation agent compound and application thereof 江苏先声药业有限公司 2025-02-14 CN disclosed
US-20250051338-A1 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-02-13 US disclosed
CN-119371371-A Compounds and compositions as PDGF receptor kinase inhibitors 日本新药株式会社 2025-01-28 CN disclosed
CN-115315421-B Compounds and compositions as PDGF receptor kinase inhibitors 日本新药株式会社 2024-12-03 CN disclosed
EP-0079630-A1 Photographic elements containing ballasted compounds AGFA-GEVAERT N.V. (BE) 1983-05-25 EP disclosed
US-4379819-A OIL SOLUBLE MONOAZO DYE CIBA-GEIGY AG (CH) 1983-04-12 US disclosed
US-4313872-A MONDAZO AND DISAZO DYES CASSELLA AKTIENGESELLSCHAFT (DE) 1982-02-02 US disclosed
US-4229344-A Monazo pigments containing hydroxynaphthoylaminobenzimidazalone radical CIBA-GEIGY CORPORATION (US) 1980-10-21 US disclosed
US-4163059-A Pesticidally active 4,5-dichloro-3-substituted-phenylimino-1,2-dithiolenes BAYER AKTIENGESELLSCHAFT (DE) 1979-07-31 US disclosed
US-4118232-A Photographic material containing sulphonic acid group containing disazo dyestuffs CIBA-GEIGY AG (CH) 1978-10-03 US disclosed
US-4094636-A DIAZOTIZATION HOECHST AKTIENGESELLSCHAFT (DT) 1978-06-13 US disclosed
US-4083842-A USEFUL AS PIGMENTS FOR SYNTHETIC POLYMERS SANDOZ LTD. (CH) 1978-04-11 US disclosed
US-4051123-A Sulfonic-acid-group containing disazo dyestuffs CIBA-GEIGY AG (CH) 1977-09-27 US disclosed
US-3953420-A Azo pigments derived from 2-hydroxy-3-carboxynaphthalene containing a substituted or unsubstituted phthalimide BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF TYK2, CSNK2A1, CSNK2A2 KDM4E 810/4885ALDH1A1 3930/4885HPGD 3257/4885
US-20250051338-A1 TYK2 DEGRADERS AND USES THEREOF TYK2, DYRK2, DYRK1A KDM4E 108/4885ALDH1A1 4504/4885HPGD 4054/4885
US-12509424-B2 Compound and composition as PDGF receptor kinase inhibitor PDGFRA, PDGFRB, PDGFA KDM4E 713/4885ALDH1A1 1938/4885HPGD 1985/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 KDM4E 2407/4885ALDH1A1 800/4885HPGD 3468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.