Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 7/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162888 | 0.85 | PLA2G2A (0.48) | PLA2G2ACNR1NUAK1JAK2NTRK1 | |
| SCHEMBL5159760 | 0.79 | KMT2A (0.49) | PLA2G2ACNR1HTTMAPK8L3MBTL1 | |
| SCHEMBL5158958 | 0.72 | PLA2G2A (0.66) | PLA2G2ANUAK1JAK2NTRK1JAK1 | |
| SCHEMBL14608169 | 0.70 | PLA2G10 (0.41) | PLA2G2AHTTPLA2G1B | |
| SCHEMBL26670917 | 0.69 | GRIN2B (0.38) | KDM2B | |
| SCHEMBL26660662 | 0.64 | KDM2B (0.44) | CNR1L3MBTL1CNR2KDM2BTDP1 | |
| SCHEMBL31501905 | 0.64 | GRM2 (0.38) | CNR1MAPK8CNR2KDM2B | |
| SCHEMBL26660745 | 0.64 | GRM2 (0.38) | CNR1MAPK8CNR2KDM2B | |
| SCHEMBL6339378 | 0.64 | PLA2G2A (0.46) | PLA2G2A | |
| SCHEMBL26670766 | 0.64 | MCL1 (0.33) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358156-B1 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1358156-B1 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-02-21 | — | — | EP | disclosed |
| US-6916840-B2 | Spla2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-07-12 | — | — | US | disclosed |
| US-20040063967-A1 | Novel spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063967-A1 | Novel spla2 inhibitors | PLA2G12A, SPINT2, PLA2G4A | PLA2G2A 16/4885CNR1 3603/4885NUAK1 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.