Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of .Beta.-Hydroxyisovaleric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| .Beta.-Hydroxyisovaleric Acid SCHEMBL1409113 | 0.94 | — | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL10277344 | 0.94 | CA4 (0.48) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL10276849 | 0.94 | — | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL723160 | 0.94 | CA4 (0.48) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL2127978 | 0.92 | CA4 (0.46) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5162721 | 0.92 | CA4 (0.46) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL32674118 | 0.85 | HMGCR (0.50) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5578340 | 0.85 | PIK3CD (0.42) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL10887232 | 0.79 | CA4 (0.43) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL38654757 | 0.74 | CA4 (0.40) | CA4HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11248146-B2 | Polyvinyl acetal resin composition, film for laminated glass, and laminated glass | SKC CO., LTD. (KR) | 2022-02-15 | — | — | US | claimed |
| CN-113166475-B | Polyvinyl acetal resin composition, film for bonded glass, and bonded glass | SKC株式会社 | 2022-01-04 | — | — | CN | claimed |
| US-20210395574-A1 | POLYVINYL ACETAL RESIN COMPOSITION, FILM FOR LAMINATED GLASS, AND LAMINATED GLASS | SKC CO., LTD. (KR) | 2021-12-23 | — | — | US | claimed |
| CN-113166475-A | Polyvinyl acetal resin composition, film for bonded glass, and bonded glass | SKC株式会社 | 2021-07-23 | — | — | CN | claimed |
| CN-111903871-A | Feed additive, low-protein feed and preparation method and application thereof | 中国科学院亚热带农业生态研究所 | 2020-11-10 | — | — | CN | claimed |
| WO-2020122355-A1 | POLYVINYL ACETAL RESIN COMPOSITION, FILM FOR LAMINATED GLASS, AND LAMINATED GLASS | 에스케이씨 주식회사 | 2020-06-18 | — | — | WO | claimed |
| WO-2016044272-A1 | METHODS OF PRESERVING MUSCLE STRENGTH DURING A PERIOD OF MUSCLE DISUSE BY ADMINISTERING BETA-HYDROXY-BETA-METHYLBUTYRATE AND GREEN TEA EXTRACT | ABBOTT LABORATORIES (US) | 2016-03-24 | — | — | WO | claimed |
| US-8785496-B2 | Method of using beta-hydroxy-beta-methylbutyrate for treating disease-associated wasting | ABBOTT LABORATORIES (US) | 2014-07-22 | — | — | US | claimed |
| US-8785495-B2 | Compositions including beta-hydroxy-beta-methylbutyrate | ABBOTT LABORATORIES (US) | 2014-07-22 | — | — | US | claimed |
| US-8778993-B2 | Method of using β-hydroxy-β-methylbutyrate for the treatment of disease conditions | ABBOTT LABORATORIES (US) | 2014-07-15 | — | — | US | claimed |
| US-20120196829-A1 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE PREVENTION AND TREATMENT OF DISEASE CONDITIONS | ABBOTT LABORATORIES (US) | 2012-08-02 | — | — | US | claimed |
| US-20120189717-A1 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE AND FATTY ACIDS FOR TREATING DISEASE-ASSOCIATED WASTING | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | US | claimed |
| US-20120189714-A1 | COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | US | claimed |
| US-20120189716-A1 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR TREATING DISEASE-ASSOCIATED WASTING | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | US | claimed |
| US-20120177752-A1 | NUTRITIONAL COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE | ABBOTT LABORATORIES (US) | 2012-07-12 | — | — | US | claimed |
| EP-1750527-A1 | COMPOSITIONS AND METHOD FOR ENHANCING THE BIOAVAILABILITY OF CALCIUM AND MAGNESIUM IN DIETARY SUPPLEMENTS AND FOOD ADDITIVES | Wiley Organics, Inc. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005096846-A1 | COMPOSITION AND METHOD FOR ENHANCING THE BIOAVAILABILITY OF CALCIUM AND MAGNESIUM IN DIETARY SUPPLEMENTS AND FOOD ADDITIVES | WILEY ORGANICS, INC. (US) | 2005-10-20 | — | — | WO | claimed |
| US-20040220266-A1 | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives | WILEY ORGANICS, INC. | 2004-11-04 | — | — | US | claimed |
| US-20040106678-A1 | Compositions for the parenteral administration of calcium and magnesium | DOBBINS THOMAS A | 2004-06-03 | — | — | US | claimed |
| US-20040048925-A1 | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives | WILEY ORGANICS, INC. | 2004-03-11 | — | — | US | claimed |