Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of .Beta.-Hydroxyisovaleric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| .Beta.-Hydroxyisovaleric Acid SCHEMBL10277344 | 0.94 | CA4 (0.48) | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5159905 | 0.94 | CA4 (0.48) | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL10276849 | 0.94 | — | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL723160 | 0.94 | CA4 (0.48) | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5162721 | 0.92 | CA4 (0.46) | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL2127978 | 0.92 | CA4 (0.46) | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL32674118 | 0.85 | HMGCR (0.50) | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5578340 | 0.85 | PIK3CD (0.42) | — | |
| SCHEMBL38654757 | 0.80 | CA4 (0.40) | — | |
| T-Butylacetic Acid SCHEMBL6500330 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510325-A | Refining method of beta-hydroxy-beta-methylbutyric acid | 湖北远大生命科学与技术有限责任公司 | 2024-02-06 | — | — | CN | claimed |
| CN-116814797-A | Primer combination for PCR identification of ground beetle medicinal materials, standard decoction and traditional Chinese medicine formula particles, application thereof and identification method | 广东一方制药有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-116004839-A | Primer for multiple STR typing of Zaocys medicinal material, standard decoction and traditional Chinese medicine formula granule, application thereof and identification method | 广东一方制药有限公司 | 2023-04-25 | — | — | CN | claimed |
| CN-116004838-A | Multiple STR typing primer for Bungarus Parvus medicinal material, standard decoction and traditional Chinese medicine formula granule, application thereof and identification method | 广东一方制药有限公司 | 2023-04-25 | — | — | CN | claimed |
| CN-115261452-A | Bombyx Batryticatus and specific PCR identification method for decoction pieces, water extract products and formula granules of Bombyx Batryticatus and application of method | 广东一方制药有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115067518-A | Composition for improving immunity of tumor patients | 广东特芯生物科技有限公司 | 2022-09-20 | — | — | CN | claimed |
| CN-115040550-A | Composition for increasing immunoglobulin G | 广东特芯生物科技有限公司 | 2022-09-13 | — | — | CN | claimed |
| CN-115040549-A | Composition for tumor | 广东特芯生物科技有限公司 | 2022-09-13 | — | — | CN | claimed |
| CN-114990230-A | Multiple specificity PCR identification method for stiff silkworm and fried stiff silkworm extract and application of multiple specificity PCR identification method in Chinese patent medicine identification | 广东一方制药有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-114657256-A | Primer combination for PCR identification of Bungarus parvus medicinal materials, standard decoction and traditional Chinese medicine formula granules, application and identification method thereof | 广东一方制药有限公司 | 2022-06-24 | — | — | CN | claimed |
| US-20120189714-A1 | COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | US | claimed |
| US-20120189716-A1 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR TREATING DISEASE-ASSOCIATED WASTING | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | US | claimed |
| US-20120177752-A1 | NUTRITIONAL COMPOSITIONS INCLUDING BETA-HYDROXY-BETA-METHYLBUTYRATE | ABBOTT LABORATORIES (US) | 2012-07-12 | — | — | US | claimed |
| CN-100542525-C | The method for preparing 3-hydroxy-3-methyl sodium butyrate solid preparation | LONZA AG (CH) | 2009-09-23 | — | — | CN | claimed |
| US-7026507-B2 | Method for the production of solid formulations of sodium 3-hydroxy-3-methylbutyrate | LONZA AG (CH) | 2006-04-11 | — | — | US | claimed |
| EP-1399138-B1 | METHOD FOR THE PRODUCTION OF SOLID FORMULATIONS OF SODIUM 3-HYDROXY-3-METHYLBUTYRATE | LONZA AG (CH) | 2006-02-08 | — | — | EP | claimed |
| CN-1523983-A | Method for preparing solid preparation of sodium 3-hydroxy-3-methylbutyrate | ��¡���ӹɷ�����˾ | 2004-08-25 | — | — | CN | claimed |
| US-20040143136-A1 | Method for the production of solid formulations of sodium 3-hydroxy-3-methylbutyrate | LONZA AG (CH) | 2004-07-22 | — | — | US | claimed |
| EP-1399138-A1 | METHOD FOR THE PRODUCTION OF SOLID FORMULATIONS OF SODIUM 3-HYDROXY-3-METHYLBUTYRATE | LONZA AG (CH) | 2004-03-24 | — | — | EP | claimed |
| WO-2002094255-A1 | METHOD FOR THE PRODUCTION OF SOLID FORMULATIONS OF SODIUM 3-HYDROXY-3-METHYLBUTYRATE | LONZA AG (CH) | 2002-11-28 | — | — | WO | claimed |