Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of .Beta.-Hydroxyisovaleric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| .Beta.-Hydroxyisovaleric Acid SCHEMBL2127978 | 0.97 | CA4 (0.46) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5162721 | 0.97 | CA4 (0.46) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL1409113 | 0.94 | — | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5159905 | 0.94 | CA4 (0.48) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL10277344 | 0.94 | CA4 (0.48) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL10276849 | 0.94 | — | — | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL32674118 | 0.90 | HMGCR (0.50) | CA4ALDH1A1HMGCRCHRM1TBXA2R | |
| .Beta.-Hydroxyisovaleric Acid SCHEMBL5578340 | 0.85 | PIK3CD (0.42) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL10887183 | 0.79 | CA4 (0.43) | CA4HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL5081009 | 0.78 | CA4 (0.50) | CA4ALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 644 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122030599-A | Chinese salty fresh full-nutrition special medical food based on flavor-physiological metabolism coupling mechanism | 陈文洁 | 2026-05-15 | — | — | CN | claimed |
| CN-122036495-A | Synthesis method of beta-hydroxy-beta-calcium methylbutyrate | 拓新药业集团股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-121574233-A | Preparation method of collagen peptide, nutrition powder composition for promoting wound healing, and preparation method, product and application thereof | 中国人民解放军总医院第四医学中心 | 2026-02-27 | — | — | CN | claimed |
| CN-120154691-A | Skin-care immunity-enhancing traditional Chinese medicine extract, female milk powder and preparation method | 逸盈养健康科技(沈阳)有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-119999924-A | Ribonucleic acid functional beverage and preparation method thereof | 山东三六九生物科技有限公司 | 2025-05-16 | — | — | CN | claimed |
| US-20250120425-A1 | Combinations of Ketogenic Supplements for Rapid and Sustained Blood Ketone Levels in Dieters and Patients | ZARPAS STEPHEN MICHAEL (US) | 2025-04-17 | — | — | US | claimed |
| CN-119745065-A | Nutritional composition for recovering osteoporotic fracture and preparation method thereof | 浙江省海洋开发研究院 | 2025-04-04 | — | — | CN | claimed |
| CN-119699591-A | Compound nutrition preparation for reducing fat and increasing muscle and preparation method thereof | 四川大学华西医院 | 2025-03-28 | — | — | CN | claimed |
| CN-119606021-A | Muscle-increasing composition, and preparation method, application and product thereof | 北京东方红航天生物技术股份有限公司 | 2025-03-14 | — | — | CN | claimed |
| CN-119563768-A | Application of beta-hydroxy-beta-methylbutyrate calcium in improving production performance of horses | 新疆农业大学 | 2025-03-07 | — | — | CN | claimed |
| US-20110250322-A1 | Plastic Packaged Nutritional Liquids Comprising HMB | ABBOTT LABORATORIES | 2011-10-13 | — | — | US | claimed |
| WO-2011094551-A1 | PLASTIC PACKAGED NUTRITONAL LIQUIDS COMPRISING HMB | ABBOTT LABORATORIES (US) | 2011-08-04 | — | — | WO | claimed |
| US-20080317886-A1 | Compositions for Preventing and Reducing Delayed Onset Muscle Soreness | SOUTHWEST IMMUNOLOGY, INC. | 2008-12-25 | — | — | US | claimed |
| EP-1973426-A2 | COMPOSITIONS FOR PREVENTING AND REDUCING DELAYED ONSET MUSCLE SORENESS | Southwest Immunology Inc. (US) | 2008-10-01 | — | — | EP | claimed |
| WO-2007056176-A2 | COMPOSITIONS FOR PREVENTING AND REDUCING DELAYED ONSET MUSCLE SORENESS | SOUTHWEST IMMUNOLOGY, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1750527-A1 | COMPOSITIONS AND METHOD FOR ENHANCING THE BIOAVAILABILITY OF CALCIUM AND MAGNESIUM IN DIETARY SUPPLEMENTS AND FOOD ADDITIVES | Wiley Organics, Inc. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005096846-A1 | COMPOSITION AND METHOD FOR ENHANCING THE BIOAVAILABILITY OF CALCIUM AND MAGNESIUM IN DIETARY SUPPLEMENTS AND FOOD ADDITIVES | WILEY ORGANICS, INC. (US) | 2005-10-20 | — | — | WO | claimed |
| US-20040220266-A1 | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives | WILEY ORGANICS, INC. | 2004-11-04 | — | — | US | claimed |
| US-20040106678-A1 | Compositions for the parenteral administration of calcium and magnesium | DOBBINS THOMAS A | 2004-06-03 | — | — | US | claimed |
| US-20040048925-A1 | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives | WILEY ORGANICS, INC. | 2004-03-11 | — | — | US | claimed |