Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083007 | 0.87 | DHODH (0.45) | DHODHHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL208794 | 0.86 | ALDH1A1 (0.44) | HPGDALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL208016 | 0.86 | HPGD (0.48) | HPGDALDH1A1MAPTKMT2AEPHX2 | |
| SCHEMBL206834 | 0.85 | DHODH (0.48) | DHODHHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL206988 | 0.84 | ALDH1A1 (0.51) | HPGDALDH1A1MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL206061 | 0.83 | ALDH1A1 (0.50) | HPGDALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL207293 | 0.81 | DHODH (0.48) | DHODHALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL208454 | 0.81 | ALDH1A1 (0.53) | HPGDALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL205392 | 0.81 | HPGD (0.46) | HPGDALDH1A1MAPTKMT2APLAAT3 | |
| SCHEMBL205940 | 0.81 | DHODH (0.55) | DHODHALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007536323-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1745010-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-01-24 | — | — | EP | claimed |
| WO-2005110974-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |