Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161243 | 0.88 | CNR1 (0.64) | CNR1ATRNPC1 | |
| SCHEMBL5163125 | 0.85 | CNR1 (0.65) | CNR1SMN1; SMN2GAAATRLMNA | |
| SCHEMBL5158397 | 0.82 | CNR1 (0.54) | CNR1ALDH1A1GAALMNAMEN1 | |
| SCHEMBL4454677 | 0.81 | CNR1 (1.00) | CNR1SMN1; SMN2GAAPRKDCATR | |
| SCHEMBL6424135 | 0.78 | CNR1 (0.93) | CNR1ALDH1A1SMN1; SMN2GAAPRKDC | |
| SCHEMBL5163182 | 0.76 | CNR1 (0.69) | CNR1LMNATP53MAPTNPC1 | |
| SCHEMBL5158234 | 0.76 | CNR1 (0.69) | CNR1ALDH1A1HTTNPSR1 | |
| SCHEMBL22204354 | 0.76 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2GAAHTTLMNA | |
| SCHEMBL27427330 | 0.74 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2GAAHTTLMNA | |
| SCHEMBL5158125 | 0.73 | CNR1 (0.65) | CNR1ALDH1A1SMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458690-B1 | 5,6-DIARYL-PYRAZINE-2-AMIDE DERIVATIVES AS CB1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | claimed |