Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163847 | 0.83 | CNR1 (0.49) | CNR1ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL5160102 | 0.82 | CNR1 (0.67) | CNR1ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL4455131 | 0.79 | CNR1 (0.67) | CNR1ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL5163182 | 0.77 | CNR1 (0.69) | CNR1LMNAMAPT | |
| SCHEMBL6454010 | 0.75 | CNR1 (0.62) | CNR1ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL9695575 | 0.75 | CNR1 (0.66) | CNR1ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL9695458 | 0.73 | THRB (0.51) | CNR1ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL9695460 | 0.73 | THRB (0.51) | CNR1ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL10508434 | 0.73 | ALDH1A1 (0.51) | CNR1ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL6223461 | 0.71 | ESR2 (0.56) | ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458690-B1 | 5,6-DIARYL-PYRAZINE-2-AMIDE DERIVATIVES AS CB1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | claimed |