Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TMPRSS4 | Q9NRS4 | 7/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MYLK | Q15746 | 1/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157924 | 0.85 | GAA (0.50) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5161867 | 0.77 | GAA (0.48) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5159560 | 0.75 | TMPRSS4 (0.55) | TMPRSS4P2RX1P2RX4P2RX7CHRNA7 | |
| SCHEMBL7484346 | 0.75 | GAA (0.48) | MEN1KMT2AALDH1A1MAPTKCNMA1 | |
| SCHEMBL5426023 | 0.74 | GAA (0.48) | MEN1KMT2AALDH1A1MAPTKCNMA1 | |
| SCHEMBL27886044 | 0.73 | RAB9A (0.62) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30100391 | 0.73 | TMPRSS4 (0.79) | TMPRSS4P2RX1P2RX4P2RX7CHRNA7 | |
| SCHEMBL18341401 | 0.73 | TMPRSS4 (0.79) | TMPRSS4P2RX1P2RX4P2RX7CHRNA7 | |
| SCHEMBL5157611 | 0.73 | MAPT (0.47) | POLBTMPRSS4ALDH1A1MAPTKCNMA1 | |
| SCHEMBL18341193 | 0.72 | TMPRSS4 (0.85) | TMPRSS4P2RX1P2RX4P2RX7CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133474-B1 | 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1133474-A4 | 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2005-02-16 | — | — | EP | disclosed |
| EP-1133474-A1 | 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6184231-B1 | NEUROPROTECTANTS; TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, TRAUMATIC BRAIN INJURY, SEXUAL DYSFUNCTION | BRISTOL-MYERS SQUIBB | 2001-02-06 | — | — | US | disclosed |
| WO-2000034244-A1 | 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-15 | — | — | WO | disclosed |