Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157924 | 0.91 | GAA (0.50) | GAASMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL5426023 | 0.91 | GAA (0.48) | GAASMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL5161867 | 0.89 | GAA (0.48) | GAASMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL5157611 | 0.88 | MAPT (0.47) | GAASMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL10676913 | 0.80 | CYP1A2 (0.54) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL5157491 | 0.78 | RECQL (0.48) | LMNAMAPTKCNMA1CYP2C9 | |
| SCHEMBL28535658 | 0.77 | ALDH1A1 (0.54) | GAASMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL9468747 | 0.75 | KMT2A (0.82) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| Formic Acid SCHEMBL5157620 | 0.75 | RORB (0.44) | LMNAMAPTKCNMA1CYP2C9 | |
| SCHEMBL5160106 | 0.75 | POLB (0.56) | KMT2AMEN1ALDH1A1MAPTKCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011677-A4 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1011677-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5972961-A | ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999009983-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |