Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 13/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5154842 | 1.00 | EPHX2 (0.42) | EPHX2MEN1KMT2AEPHX1TSHR | |
| SCHEMBL6337635 | 0.82 | TSHR (0.49) | EPHX2MEN1KMT2AEPHX1TSHR | |
| SCHEMBL28239603 | 0.77 | MAOB (0.33) | — | |
| SCHEMBL3916424 | 0.75 | EPHX2 (0.45) | EPHX2MEN1KMT2AEPHX1TSHR | |
| SCHEMBL5157490 | 0.72 | EPHX2 (0.53) | EPHX2MEN1KMT2ATSHR | |
| SCHEMBL5161048 | 0.72 | EPHX2 (0.47) | EPHX2MEN1KMT2AEPHX1TSHR | |
| SCHEMBL2498573 | 0.71 | PIK3C3 (0.32) | — | |
| Hydrochloric Acid SCHEMBL5157992 | 0.71 | KMT2A (0.48) | EPHX2MEN1KMT2AEPHX1TSHR | |
| SCHEMBL3918340 | 0.64 | EPHX2 (0.67) | EPHX2MEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL7353899 | 0.62 | EPHX2 (0.59) | EPHX2MEN1KMT2AEPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |