Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5157992 | 0.99 | KMT2A (0.48) | EPHX2KMT2AMEN1TSHREPHX1 | |
| SCHEMBL5161039 | 0.76 | HSD11B1 (0.52) | EPHX2HSD11B1 | |
| Hydrochloric Acid SCHEMBL5157982 | 0.75 | HSD11B1 (0.51) | EPHX2HSD11B1 | |
| SCHEMBL5157490 | 0.74 | EPHX2 (0.53) | EPHX2KMT2AMEN1TSHRHSD11B1 | |
| SCHEMBL18709829 | 0.72 | FKBP1A (0.42) | TSHRSMN1; SMN2KDM4E | |
| SCHEMBL15114564 | 0.72 | FKBP1A (0.42) | TSHRSMN1; SMN2KDM4E | |
| SCHEMBL5154842 | 0.72 | EPHX2 (0.42) | EPHX2KMT2AMEN1TSHREPHX1 | |
| SCHEMBL5160186 | 0.72 | EPHX2 (0.42) | EPHX2KMT2AMEN1TSHREPHX1 | |
| SCHEMBL10263338 | 0.71 | GAA (0.41) | TSHRKDM4E | |
| SCHEMBL1804303 | 0.70 | MAOB (0.41) | TSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | EPHX2 2185/4885KMT2A 3470/4885MEN1 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.