Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163081 | 0.91 | OPRL1 (0.35) | CCR5MEN1KMT2AOPRL1OPRM1 | |
| SCHEMBL6936762 | 0.89 | SLC6A9 (0.39) | OPRL1OPRM1SLC6A4SLC6A3KDR | |
| SCHEMBL6938861 | 0.88 | GRIN2B (0.39) | OPRL1TRPA1 | |
| SCHEMBL5163369 | 0.88 | CCR5 (0.38) | CCR5TRPA1 | |
| Hydrochloric Acid SCHEMBL7741182 | 0.88 | OPRL1 (0.39) | OPRL1OPRM1SLC6A4SLC6A3KDR | |
| SCHEMBL5845135 | 0.87 | CCR5 (0.41) | CCR5MEN1KMT2AOPRL1OPRM1 | |
| SCHEMBL5845800 | 0.87 | SLC6A4 (0.42) | CCR5MEN1KMT2AOPRL1OPRM1 | |
| SCHEMBL5162722 | 0.87 | SLC6A2 (0.45) | OPRL1OPRM1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL5846073 | 0.86 | SLC6A2 (0.42) | CCR5MEN1KMT2AOPRM1SLC6A2 | |
| Hydrochloric Acid SCHEMBL5846901 | 0.86 | CCR5 (0.40) | CCR5OPRL1OPRM1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1406857-B1 | SUBSTITUTED 1-ARYL-BUT-3-ENYLAMINE AND 1-ARYL-BUT-2-ENYLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2007-02-21 | — | — | EP | disclosed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |