Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 12/20 | 0.55 |
| ▸ | MMP13 | P45452 | 7/20 | 0.55 |
| ▸ | MMP12 | P39900 | 6/20 | 0.55 |
| ▸ | MMP3 | P08254 | 4/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165108 | 1.00 | MMP8 (0.55) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5163127 | 1.00 | MMP8 (0.55) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5165977 | 0.93 | MMP8 (0.52) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5164001 | 0.93 | MMP8 (0.52) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5445135 | 0.88 | MMP8 (0.51) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5437023 | 0.88 | MMP8 (0.51) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5437350 | 0.88 | MMP8 (0.51) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5165907 | 0.86 | MMP8 (0.51) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL14427166 | 0.84 | MMP8 (0.62) | MMP8MMP13MMP12MMP3MMP1 | |
| SCHEMBL5445437 | 0.81 | MMP8 (0.54) | MMP8MMP13MMP12MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |