Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 13/20 | 0.52 |
| ▸ | MMP13 | P45452 | 5/20 | 0.52 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | MMP12 | P39900 | 5/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MMP15 | P51511 | 1/20 | 0.37 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164001 | 1.00 | MMP8 (0.52) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5160313 | 0.93 | MMP8 (0.55) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5163127 | 0.93 | MMP8 (0.55) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5165108 | 0.93 | MMP8 (0.55) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5445437 | 0.89 | MMP8 (0.54) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5449079 | 0.89 | MMP8 (0.54) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5444979 | 0.89 | MMP8 (0.54) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5163157 | 0.85 | MMP12 (0.42) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL14427177 | 0.85 | MMP8 (0.54) | MMP8MMP13MMP3MMP12MMP1 | |
| SCHEMBL5165907 | 0.83 | MMP8 (0.51) | MMP8MMP13MMP3MMP12MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |