Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160387 | 1.00 | ALDH1A1 (0.50) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL5162886 | 0.82 | ALDH1A1 (0.60) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL5157973 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL5160873 | 0.77 | MAPT (0.57) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL5163048 | 0.76 | ALDH1A1 (0.58) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL5158077 | 0.72 | ALDH1A1 (0.48) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL8992691 | 0.69 | NPY5R (0.51) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29140944 | 0.67 | NPY5R (0.78) | ALDH1A1MAPTNPY5RMEN1KMT2A | |
| SCHEMBL5160351 | 0.67 | EPHX2 (0.46) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL9724950 | 0.64 | ALDH1A1 (0.54) | ALDH1A1MAPTALOX15SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753733-A1 | SMALL MOLECULES FOR TREATMENT OF HYPERCHOLESTEROLEMIA AND RELATED DISEASES | Avanir Pharmaceuticals (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123700-A1 | SMALL MOLECULES FOR TREATMENT OF HYPERCHOLESTEROLEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |