Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | RAC1 | P63000 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158212 | 0.92 | MAPT (0.43) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3164927 | 0.90 | MAPT (0.41) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL29565400 | 0.90 | MAPT (0.41) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL7001887 | 0.88 | EGFR (0.41) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8919915 | 0.84 | MEN1 (0.38) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL12610521 | 0.84 | MAPT (0.34) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL6169861 | 0.83 | ATM (0.41) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL12610577 | 0.82 | NR1H2 (0.33) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3830804 | 0.81 | ALDH1A1 (0.42) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL10106951 | 0.79 | ATM (0.39) | MAPTRAB9ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000025-B1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2007-02-21 | — | — | EP | claimed |
| US-5658500-A | REVERSIBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 1997-08-19 | — | — | US | claimed |
| EP-1000025-B1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2007-02-21 | — | — | EP | disclosed |
| US-5658500-A | REVERSIBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 1997-08-19 | — | — | US | disclosed |