Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10106951 | 0.96 | ATM (0.39) | ATML3MBTL1EGFRTDP1CA1 | |
| SCHEMBL7001887 | 0.92 | EGFR (0.41) | ATML3MBTL1EGFRALDH1A1HIF1A | |
| SCHEMBL15254539 | 0.92 | KDM4E (0.39) | ATML3MBTL1EGFRTDP1CA1 | |
| SCHEMBL9280386 | 0.91 | ATM (0.38) | ATML3MBTL1EGFRTDP1CA1 | |
| SCHEMBL1408896 | 0.89 | ATM (0.41) | ATML3MBTL1TDP1CA1CA2 | |
| SCHEMBL29565080 | 0.89 | ATM (0.41) | ATML3MBTL1TDP1CA1CA2 | |
| SCHEMBL8978512 | 0.89 | ATM (0.41) | ATML3MBTL1TDP1CA1CA2 | |
| SCHEMBL1333703 | 0.89 | ATM (0.39) | ATML3MBTL1EGFRTDP1HTT | |
| SCHEMBL9912574 | 0.89 | L3MBTL1 (0.37) | ATML3MBTL1TDP1CA1CA2 | |
| SCHEMBL13988301 | 0.89 | L3MBTL1 (0.37) | ATML3MBTL1EGFRTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | claimed |
| WO-1995016215-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1995-06-15 | — | — | WO | claimed |
| US-7465415-B2 | Photochromic materials derived from ring-opening monomers and photochromic initiators | PPG INDUSTRIES OHIO, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| EP-1112263-B1 | POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1112264-B1 | POLYALKOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1037885-B1 | NOVEL WATER SOLUBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6113814-A | PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. | TRANSITIONS OPTICAL, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| US-5961892-A | PHOTOCHROMIC | PPG INDUSTRIES OHIO, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5879592-A | Water soluble photochromic compounds, compositions and optical elements comprising the compounds | PPG INDUSTRIES, INC. (US) | 1999-03-09 | — | — | US | disclosed |
| US-5650098-A | PHOTOCHROMIC LENSES | TRANSITIONS OPTICAL, INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5573712-A | PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN | TRANSITIONS OPTICAL, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |