Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.49 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160855 | 0.97 | ADORA2A (0.50) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL5177683 | 0.90 | ADORA2A (0.57) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL1286132 | 0.88 | ADORA2A (0.57) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL1286288 | 0.87 | ADORA2A (0.64) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL5161279 | 0.87 | ADORA2A (0.56) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL5162437 | 0.84 | ADORA2A (0.61) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL5161328 | 0.84 | ADORA2A (0.46) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL5367591 | 0.83 | ADORA2A (0.50) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL5367588 | 0.83 | ADORA2A (0.50) | ADORA2AADORA1TMIGD3ADORA3ADORA2B | |
| SCHEMBL1286303 | 0.83 | ADORA2A (0.56) | ADORA2AADORA1TMIGD3ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189730-B2 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1456209-B1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20030149060-A1 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149060-A1 | A2A adenosine receptor antagonists | ADORA2A, ADORA2B, ADORA3 | ADORA2A 1/4885ADORA1 4/4885TMIGD3 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.