Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.64 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30868543 | 0.91 | P2RX1 (0.61) | PTGS1TLR8P2RX1P2RX4P2RX7 | |
| SCHEMBL678096 | 0.89 | PTGS1 (0.64) | PTGS1TLR8P2RX1P2RX4P2RX7 | |
| SCHEMBL5437515 | 0.87 | TLR8 (0.55) | PTGS1TLR8RETP2RX1P2RX4 | |
| SCHEMBL17664550 | 0.86 | TLR8 (0.54) | PTGS1TLR8RETP2RX1P2RX4 | |
| SCHEMBL17660212 | 0.85 | TLR8 (0.54) | TLR8RETP2RX1P2RX4P2RX7 | |
| SCHEMBL29286666 | 0.84 | TMPRSS4 (0.59) | PTGS1TMPRSS4MEN1KMT2ALCK | |
| SCHEMBL6816710 | 0.82 | LMNA (0.57) | PTGS1P2RX1LMNAMAPTMEN1 | |
| SCHEMBL6792746 | 0.80 | PTGS1 (0.57) | PTGS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL14410670 | 0.80 | RXFP1 (0.57) | PTGS1TLR8RETP2RX1P2RX4 | |
| SCHEMBL18146857 | 0.79 | LMNA (0.61) | P2RX1JAK2TYK2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101952287-B | Protein kinase inhibitors and use thereof | MERCK SERONO SA | 2013-11-27 | — | — | CN | disclosed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
| CN-1938282-A | Imidazole derivatives as tyrosine kinase inhibitors | MERCK PATENT GMBH (DE) | 2007-03-28 | — | — | CN | disclosed |
| EP-1761503-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005097755-A2 | IMIDAZOL DERIVATIVES AS TYROSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | TIE1, FLT1, FER | PTGS1 1533/4885TLR8 1834/4885RET 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.