Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | DAO | P14920 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CCKAR | P32238 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2605497 | 0.85 | FLT3 (0.65) | KDM4EHPGDMAPTDAOSRD5A2 | |
| SCHEMBL30790269 | 0.85 | FLT3 (0.65) | KDM4EHPGDMAPTDAOSRD5A2 | |
| SCHEMBL5160307 | 0.84 | KDM4E (0.58) | KDM4EHPGDMAPTDAOSRD5A2 | |
| SCHEMBL5161469 | 0.81 | KDM4E (0.58) | KDM4EHPGDMAPTDAOSRD5A2 | |
| Indole-2-Carboxylic Acid SCHEMBL28209082 | 0.79 | KDM4E (0.96) | KDM4EHPGDMAPTDAOSRD5A2 | |
| Indole-2-Carboxylic Acid SCHEMBL31620677 | 0.79 | KDM4E (0.96) | KDM4EHPGDMAPTDAOSRD5A2 | |
| Indole-2-Carboxylic Acid SCHEMBL27530753 | 0.79 | KDM4E (0.96) | KDM4EHPGDMAPTDAOSRD5A2 | |
| SCHEMBL5973083 | 0.78 | KDM4E (0.58) | KDM4EHPGDMAPTDAOSRD5A2 | |
| SCHEMBL8670236 | 0.77 | CCKAR (0.77) | KDM4EHPGDMAPTDAOSRD5A2 | |
| SCHEMBL8670229 | 0.77 | CCKAR (0.77) | KDM4EHPGDMAPTDAOSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340746-B1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | SALTIGO GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1340746-A1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |