Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 1/20 | 0.77 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | PYGL | P06737 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | DAO | P14920 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670236 | 1.00 | CCKAR (0.77) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL29949076 | 0.86 | DRD2 (0.68) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL13753384 | 0.86 | DRD2 (0.68) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL6446972 | 0.86 | HSPA5 (0.60) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL6446970 | 0.86 | HSPA5 (0.60) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL6883379 | 0.84 | MEN1 (0.64) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL19476075 | 0.84 | MEN1 (0.64) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL17149629 | 0.84 | MEN1 (0.64) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL9471760 | 0.84 | CCKAR (0.58) | CCKARDRD2LMNANPC1RAB9A | |
| SCHEMBL13753482 | 0.84 | DRD2 (0.64) | CCKARDRD2LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106456602-B | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2020-11-24 | — | — | CN | disclosed |
| US-5707991-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1998-01-13 | — | — | US | disclosed |
| EP-0270234-A2 | Renin inhibitors | PFIZER INC. (US) | 1988-06-08 | — | — | EP | disclosed |