Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.76 |
| ▸ | TMIGD3 | P0DMS9 | 7/20 | 0.76 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.65 |
| ▸ | CDK1 | P06493 | 4/20 | 0.64 |
| ▸ | CFTR | P13569 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163682 | 0.93 | ADORA1 (0.75) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL5163818 | 0.87 | ADORA2A (0.85) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL5161098 | 0.86 | ADORA2A (1.00) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL15756430 | 0.86 | ADORA2A (0.73) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL5161308 | 0.86 | ADORA2A (0.87) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL17802554 | 0.85 | ADORA2A (0.78) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL5161353 | 0.85 | TMIGD3 (0.88) | ADORA2AADORA1TMIGD3ADORA2BCFTR | |
| SCHEMBL5161096 | 0.84 | TMIGD3 (0.86) | ADORA2AADORA1TMIGD3ADORA2BCFTR | |
| SCHEMBL5163911 | 0.83 | ADORA2A (0.76) | ADORA2AADORA1TMIGD3ADORA2BCDK1 | |
| SCHEMBL5357328 | 0.82 | ADORA2A (0.77) | ADORA2AADORA1TMIGD3ADORA2BCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189730-B2 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1456209-B1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1456209-A1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20030149060-A1 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2003-08-07 | — | — | US | disclosed |
| WO-2003051882-A1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149060-A1 | A2A adenosine receptor antagonists | ADORA2A, ADORA2B, ADORA3 | ADORA2A 1/4885ADORA1 4/4885TMIGD3 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.