Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 10/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.51 |
| ▸ | TMIGD3 | P0DMS9 | 5/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161094 | 0.95 | ADORA2A (0.51) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5178361 | 0.88 | ADORA2A (0.59) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5160279 | 0.85 | ADORA1 (0.51) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5162984 | 0.85 | ADORA1 (0.53) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5163815 | 0.83 | ADORA2A (0.59) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5160437 | 0.83 | ADORA2A (0.61) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5161406 | 0.83 | ADORA1 (0.51) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5161297 | 0.82 | ADORA2A (0.60) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5161872 | 0.82 | ADORA2A (0.56) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 | |
| SCHEMBL5161362 | 0.82 | ADORA1 (0.51) | ADORA1ADORA2AADORA2BTMIGD3ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189730-B2 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1456209-B1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20030149060-A1 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149060-A1 | A2A adenosine receptor antagonists | ADORA2A, ADORA2B, ADORA3 | ADORA1 4/4885ADORA2A 1/4885ADORA2B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.