Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384509 | 0.89 | KDM4E (0.61) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL68630 | 0.88 | LMNA (0.50) | KDM4EALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL4554338 | 0.88 | ALOX5 (0.50) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL20531407 | 0.86 | MAPT (0.52) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL18927126 | 0.83 | KDM4E (0.49) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL19760841 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17917512 | 0.82 | KDM4E (0.58) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17917511 | 0.82 | KDM4E (0.48) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL17917527 | 0.82 | MAPT (0.46) | KDM4EHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL14825579 | 0.81 | ALOX5 (0.48) | KDM4EHDAC1HDAC8HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028968-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-02-02 | — | — | US | disclosed |
| WO-2010086279-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028968-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | CHRNA10, CHRNA6, CHRNA7 | KDM4E 2635/4885HDAC1 2099/4885HDAC8 2677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.