Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LAP3 | P28838 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Alanine SCHEMBL3421250 | 1.00 | ALDH1A1 (0.53) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| Alanine SCHEMBL9439316 | 1.00 | ALDH1A1 (0.53) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL93452 | 0.91 | ALDH1A1 (0.61) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL93453 | 0.91 | ALDH1A1 (0.61) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL93451 | 0.91 | ALDH1A1 (0.61) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| Alanine SCHEMBL8350844 | 0.89 | ALDH1A1 (0.44) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| Ammonia Solution, Strong SCHEMBL4650725 | 0.89 | ALDH1A1 (0.59) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL19924628 | 0.89 | ALDH1A1 (0.59) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| Ammonia Solution, Strong SCHEMBL4650728 | 0.89 | ALDH1A1 (0.59) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL7611218 | 0.89 | ALDH1A1 (0.59) | ALDH1A1LAP3MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028905-A1 | Isolation, Purification, and Structure Elucidation of the Antiproliferative Compound Coibamide A | The State of Oregon, Acting by and through the State Board of Higher Education on behalf of | 2012-02-02 | — | — | US | disclosed |
| US-8034780-B2 | Isolation, purification, and structure elucidation of the antiproliferative compound coibamide A | SMITHSONIAN TROPICAL RESEARCH INSTITUTE | 2011-10-11 | — | — | US | disclosed |
| US-20090023642-A1 | Isolation, Purification, and Structure Elucidation of the Antiproliferative Compound Coibamide A | THE STATE OF OREGON, ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY | 2009-01-22 | — | — | US | disclosed |
| US-5350574-A | Immunosuppressive agent for preventing organ rejection | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1994-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023642-A1 | Isolation, Purification, and Structure Elucidation of the Antiproliferative Compound Coibamide A | TOP2B, MCL1, MKI67 | ALDH1A1 2450/4885LAP3 2342/4885MEN1 1903/4885 |
| US-20120028905-A1 | Isolation, Purification, and Structure Elucidation of the Antiproliferative Compound Coibamide A | TOP2B, MCL1, MKI67 | ALDH1A1 2450/4885LAP3 2342/4885MEN1 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.