Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PRCP | P42785 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161528 | 0.87 | TSHR (0.54) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL16223395 | 0.87 | TSHR (0.58) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL758937 | 0.87 | TSHR (0.58) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL16223438 | 0.87 | TSHR (0.58) | TSHRNPSR1PRCPGAAOPRM1 | |
| Bromide SCHEMBL9255826 | 0.84 | TSHR (0.51) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL27907751 | 0.83 | TSHR (0.50) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL30519196 | 0.80 | OPRM1 (0.54) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL1404150 | 0.77 | TSHR (0.71) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL327054 | 0.76 | PRCP (0.56) | TSHRNPSR1PRCPGAAOPRM1 | |
| SCHEMBL31062461 | 0.76 | PRCP (0.56) | TSHRNPSR1PRCPGAAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |