Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.51 |
| ▸ | BCL2 | P10415 | 5/20 | 0.51 |
| ▸ | RPA1 | P27694 | 4/20 | 0.50 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163560 | 0.91 | MARS1 (0.46) | MDM2MCL1BCL2RPA1PPP1CA | |
| SCHEMBL5978029 | 0.88 | MARS1 (0.46) | MDM2MCL1BCL2RPA1PPP1CA | |
| SCHEMBL4932600 | 0.87 | CA9 (0.52) | MDM2MCL1BCL2KMT2AMEN1 | |
| SCHEMBL27668640 | 0.87 | RPA1 (0.42) | MDM2MCL1BCL2RPA1PPP1CA | |
| SCHEMBL5979572 | 0.80 | MDM2 (0.73) | MDM2MCL1BCL2RPA1PPP1CA | |
| SCHEMBL5527519 | 0.79 | CNR1 (0.45) | MDM2MCL1BCL2MARS1CACNA1G | |
| SCHEMBL4927603 | 0.79 | KMT2A (0.49) | MDM2MCL1BCL2KMT2AMEN1 | |
| SCHEMBL17005383 | 0.78 | ALDH1A1 (0.51) | MDM2MCL1BCL2RPA1PPP1CA | |
| SCHEMBL5979098 | 0.78 | RPA1 (0.61) | MDM2MCL1BCL2RPA1PPP1CA | |
| SCHEMBL5269424 | 0.77 | CA9 (0.46) | MDM2MCL1BCL2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1980912-A | Pyrazole derivatives | DAIICHI SEIYAKU CO (JP) | 2007-06-13 | — | — | CN | disclosed |
| EP-1762568-A1 | PYRAZOLE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-03-14 | — | — | EP | disclosed |
| CN-1902191-A | Amidopyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2007-01-24 | — | — | CN | disclosed |