Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165966 | 0.81 | MAPT (0.78) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL12955563 | 0.79 | PARP1 (0.65) | MAPTSMN1; SMN2LMNAPARP1AR | |
| SCHEMBL5163926 | 0.78 | MAPT (0.64) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL5165083 | 0.76 | HTT (1.00) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL5160111 | 0.74 | MAPT (0.75) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL5160240 | 0.74 | MAPT (1.00) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL6326092 | 0.73 | MAPT (0.61) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL5605032 | 0.72 | MAPT (0.62) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL10055021 | 0.72 | NPSR1 (0.55) | MAPTSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL5161752 | 0.71 | MAPT (1.00) | MAPTSMN1; SMN2HTTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231982-B1 | USE OF PHTHALAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ABBOTT GMBH & CO KG (DE) | 2007-03-21 | — | — | EP | disclosed |
| US-6903098-B1 | Use of phthalazine derivatives | ABBOTT GMBH & CO. (DE) | 2005-06-07 | — | — | US | disclosed |