Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.44 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6271133 | 0.79 | CXCR4 (0.35) | ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL4658026 | 0.79 | CCR3 (0.63) | CCR3ALDH1A1PRMT6CARM1PRMT3 | |
| SCHEMBL3757507 | 0.76 | CCR3 (0.47) | CCR3ALDH1A1PRMT6CARM1PRMT3 | |
| SCHEMBL4658054 | 0.74 | CCR3 (0.60) | CCR3ALDH1A1PRMT6CARM1PRMT3 | |
| SCHEMBL5177492 | 0.72 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPT | |
| SCHEMBL4657913 | 0.71 | CCR3 (0.56) | CCR3ALDH1A1PRMT6CARM1PRMT3 | |
| SCHEMBL3757509 | 0.70 | MEN1 (0.54) | CCR3ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL5175965 | 0.70 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPT | |
| SCHEMBL2004615 | 0.69 | CCR3 (1.00) | CCR3ALDH1A1PRMT6CARM1PRMT3 | |
| SCHEMBL7032518 | 0.69 | CCR3 (0.56) | CCR3ALDH1A1PRMT6CARM1PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | claimed |
| EP-1751101-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113497-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROL-2-CARBXYLIC ACID AMIDES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |