Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163905 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL5166693 | 0.74 | NR3C2 (0.57) | SMN1; SMN2ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL5166956 | 0.73 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL5166003 | 0.72 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5891884 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1NR3C1PGRL3MBTL1 | |
| SCHEMBL5167263 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL5892016 | 0.69 | CYP19A1 (0.57) | SMN1; SMN2ALDH1A1L3MBTL1CNR1CYP1A2 | |
| SCHEMBL5164007 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL17580040 | 0.69 | MAOA (0.57) | SMN1; SMN2ALDH1A1MAOAL3MBTL1POLB | |
| SCHEMBL25856992 | 0.68 | RAB9A (0.52) | SMN1; SMN2ALDH1A1CYP3A4HPGDRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | PTPA, PTPN1, PTPRS | SMN1; SMN2 3478/4885ALDH1A1 3296/4885BRD4 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.