Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516861 | 0.91 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL2114381 | 0.84 | CHRNA7 (0.51) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL5218174 | 0.82 | CHRNA7 (0.65) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL2113274 | 0.77 | CHRNA7 (0.60) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL5220969 | 0.76 | CHRNA7 (0.56) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL2112312 | 0.76 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL2113253 | 0.76 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL5216874 | 0.75 | CHRNA7 (0.50) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL2111723 | 0.75 | CHRNA7 (0.64) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Fumaric Acid SCHEMBL1759127 | 0.75 | CHRNA7 (0.49) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028968-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028968-A1 | NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | CHRNA10, CHRNA6, CHRNA7 | KCNH2 957/4885CHRM3 12/4885CHRNA7 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.