SCHEMBL5164130

SCHEMBL5164130

COc1cc(NC(=O)C(Nc2cccc(CN)c2)c2ccccc2F)ccc1N1CCCCC1=O

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F10 P00742 2/20 0.42
MAPT P10636 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
PIP4K2A P48426 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5166110 0.91 F10 (0.46) F10
SCHEMBL5164612 0.90 F10 (0.44) F10
Hydrochloric Acid SCHEMBL28750046 0.90 F10 (0.45) F10
SCHEMBL5164036 0.90 F10 (0.45) F10
SCHEMBL5165571 0.89 F10 (0.43) F10
SCHEMBL5165717 0.89 F10 (0.54) F10MAPTSMN1; SMN2
SCHEMBL5164146 0.88 F10 (0.42) F10SMN1; SMN2
SCHEMBL5165540 0.88 F10 (0.41) F10
Hydrochloric Acid SCHEMBL27601717 0.87 F10 (0.42) F10SMN1; SMN2
Hydrochloric Acid SCHEMBL27601432 0.87 F10 (0.41) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7273867-B2 Phenyl derivatives MERCK PATENT GMBH (DE) 2007-09-25 US claimed
EP-1351938-B1 PHENYL DERIVATIVES MERCK PATENT GMBH (DE) 2007-04-11 EP claimed
US-20040087582-A1 Phenyl derivatives MERCK PATENT GESELLSCHAFT (DE) 2004-05-06 US claimed
US-7273867-B2 Phenyl derivatives MERCK PATENT GMBH (DE) 2007-09-25 US disclosed
EP-1351938-B1 PHENYL DERIVATIVES MERCK PATENT GMBH (DE) 2007-04-11 EP disclosed
US-20040087582-A1 Phenyl derivatives MERCK PATENT GESELLSCHAFT (DE) 2004-05-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040087582-A1 Phenyl derivatives F2, F11, SERPINC1 F10 6/4885MAPT 4360/4885SMN1; SMN2 3430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.