Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035482 | 0.79 | MEN1 (0.41) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL5164769 | 0.75 | HTR2A (0.36) | MEN1KMT2A | |
| SCHEMBL6897901 | 0.75 | CYP3A4 (0.41) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL8792376 | 0.73 | MEN1 (0.48) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL11712126 | 0.72 | SLC6A3 (0.40) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL11715216 | 0.70 | NR4A1 (0.44) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL11715498 | 0.69 | SLC6A3 (0.36) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL6701385 | 0.69 | SLC6A3 (0.42) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8792804 | 0.68 | MEN1 (0.43) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL8587501 | 0.68 | MEN1 (0.43) | SLC6A3SLC6A2SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765808-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006012308-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |