Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 7/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 6/20 | 0.40 |
| ▸ | MMP13 | P45452 | 4/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165142 | 1.00 | MMP1 (0.44) | MMP1LIPEMMP12MMP8MMP3 | |
| SCHEMBL5165889 | 0.93 | MMP1 (0.47) | MMP1MMP12MMP8MMP3MMP9 | |
| SCHEMBL5162223 | 0.93 | MMP1 (0.47) | MMP1MMP12MMP8MMP3MMP9 | |
| SCHEMBL5163767 | 0.93 | MMP1 (0.47) | MMP1MMP12MMP8MMP3MMP9 | |
| SCHEMBL5164082 | 0.90 | MMP1 (0.48) | MMP1MMP12MMP8MMP3MMP9 | |
| SCHEMBL5162618 | 0.90 | MMP1 (0.48) | MMP1MMP12MMP8MMP3MMP9 | |
| SCHEMBL5430840 | 0.90 | MMP8 (0.42) | MMP1LIPEMMP12MMP8MMP3 | |
| SCHEMBL5437373 | 0.90 | MMP8 (0.42) | MMP1LIPEMMP12MMP8MMP3 | |
| SCHEMBL5191360 | 0.89 | MMP1 (0.42) | MMP1LIPEMMP12MMP8MMP3 | |
| SCHEMBL5163191 | 0.89 | MMP1 (0.42) | MMP1LIPEMMP12MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |