SCHEMBL5165682

SCHEMBL5165682

CC(=O)N(c1c(-c2ccc(OC(=O)O)o2)nc2cc(C)cc(C)n12)C(C)(C)CC(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 1/20 0.35
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5165680 0.86 CREBBP (0.37) CREBBPKMT2A
SCHEMBL5167192 0.85 CREBBP (0.35) CREBBPKMT2A
SCHEMBL5168404 0.83 RAB9A (0.35)
SCHEMBL5166413 0.82 CREBBP (0.37) CREBBPKMT2A
SCHEMBL5167270 0.81 MEN1 (0.36) CREBBPKMT2A
SCHEMBL5166910 0.80 CREBBP (0.42) CREBBPKMT2A
SCHEMBL5168909 0.79 CREBBP (0.45) CREBBPKMT2A
SCHEMBL5169200 0.78
SCHEMBL5164581 0.78 CREBBP (0.42) CREBBPKMT2A
SCHEMBL5167454 0.77 MEN1 (0.37) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326613-B2 USE OF SUBSTITUTED IMIDAZO 1,2-A|PYRIDINE-, IMIDAZO ¬1,2-A|PYRIMIDINE AND IMIDAZO ¬1,2-A|PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS GRUENENTHAL GMBH (DE) 2007-04-18 EP disclosed
EP-1326613-B1 USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO [1,2-A]PYRIMIDINE AND IMIDAZO [1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS GRUENENTHAL GMBH (DE) 2004-06-02 EP disclosed