Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 6/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.34 |
| ▸ | PLK4 | O00444 | 3/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.34 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.34 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166530 | 0.89 | GAA (0.40) | GAACDC7PLK4DYRK3PRKD3 | |
| SCHEMBL5167270 | 0.86 | MEN1 (0.36) | CREBBPGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5168168 | 0.85 | GAA (0.42) | GAAALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL5166910 | 0.85 | CREBBP (0.42) | CREBBPGAASMN1; SMN2KMT2AMAPT | |
| SCHEMBL5167192 | 0.84 | CREBBP (0.35) | CREBBPGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL5165680 | 0.84 | CREBBP (0.37) | CREBBPALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5168909 | 0.84 | CREBBP (0.45) | CREBBPGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL5164581 | 0.82 | CREBBP (0.42) | CREBBPGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5165682 | 0.82 | CREBBP (0.35) | CREBBPKMT2A | |
| SCHEMBL5167386 | 0.82 | CREBBP (0.38) | CREBBPGAAKMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040023972-A1 | Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS | GRUENENTHAL GMBH (DE) | 2004-02-05 | — | — | US | claimed |
| EP-1326613-B2 | USE OF SUBSTITUTED IMIDAZO 1,2-A|PYRIDINE-, IMIDAZO ¬1,2-A|PYRIMIDINE AND IMIDAZO ¬1,2-A|PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1326613-B1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO [1,2-A]PYRIMIDINE AND IMIDAZO [1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-06-02 | — | — | EP | disclosed |
| US-20040023972-A1 | Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS | GRUENENTHAL GMBH (DE) | 2004-02-05 | — | — | US | disclosed |
| EP-1326613-A1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO 1,2-A]PYRIMIDINE AND IMIDAZO 1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | Grünenthal GmbH (DE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030428-A1 | USE OF SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-, IMIDAZO[1,2-A]PYRIMIDINE AND IMIDAZO[1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023972-A1 | Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS | NOS1, PTGIS, NOS2 | CREBBP 1065/4885GAA 536/4885CDC7 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.